Work

Supplementary Figure S4 from Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure S4. (A) Comparison between human and mouse wild-type (WT) calreticulin Cterminal tail. Blues indicates non-conserved regions between human and mouse. The wild-type proteins are highly conserved between the two species and contain many negatively-charged glutamic acid (E) amino acids. (B) Comparison between human and mouse amino acid sequences corresponding to the mutant C-terminal part of the human and mouse mutant with red shading indicating non-conserved regions. Despite the large number of mismatches, both mutant C-terminal tails are rich in positively charged amino acids (arginine (R) and lysine (K)).

DOI: 10.1158/2159-8290.22531503

Authors: Shannon Elf, Nouran S. Abdelfattah, Edwin Chen, Javier Perales-Patón, Emily A. Rosen, Amy Ko, Fabian Peisker, Natalie Florescu, Silvia Giannini, Ofir Wolach, Elizabeth A. Morgan, Zuzana Tothova, Julie-Aurore Losman, Rebekka K. Schneider, Fatima Al-Shahrour, Ann Mullally

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362538645

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