Work

Supplementary Figures S1 - S5 from A Genetic Platform to Model Sarcomagenesis from Primary Adult Mesenchymal Stem Cells

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure S1. Candidate genes that couple with p53 loss to transform MSCs. Supplementary Figure S2. Lrf plays as oncosuppressor triggering tumorigenesis in MSCs. Supplementary Figure S3. Lrf expression does not affect the CFU-F capacities of MSCs nor it triggers MSCs to senescence or apoptosis. Supplementary Figure S4. Lrf regulates the differentiation process of MSCs through the repression of Dlk1. Supplementary Figure S5. Lrf plays a role as oncosuppressor in triggering the tumorigenesis of MSCs through Sox9 and Dlk1.

DOI: 10.1158/2159-8290.22530059

Authors: Jlenia Guarnerio, Luisa Riccardi, Riccardo Taulli, Takahiro Maeda, Guocan Wang, Robin M. Hobbs, Min Sup Song, Paolo Sportoletti, Rosa Bernardi, Roderick T. Bronson, Mireia Castillo-Martin, Carlos Cordon-Cardo, Andrea Lunardi, Pier Paolo Pandolfi

Language: English

Topic: Mesenchymal stem cell research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362538672

Cites:

Cited by:

Related to: 10