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Supplementary Figure 2 from Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax

Year: 2023
Type: supplementary-materials
Abstract: Venetoclax induces dose-dependent apoptotic cell death in BPDCN and AML cell lines. (A) Representative Annexin V-FITC vs propidium iodide (PI) flow cytometry staining to measure apoptosis induction in CAL1 cells after 24 hours of exposure to vehicle, or 10 nM or 100 nM venetoclax are shown. (B) Quantitation of cell death by Annexin V and PI flow cytometry after 24 hours of exposure to the indicated concentrations of venetoclax. Graphs represent mean +/- SEM of 3 independent experiments, *P<0.05 by t-test compared to vehicle.
DOI: 10.1158/2159-8290.22531392.v1
Authors: Joan Montero, Jason Stephansky, Tianyu Cai, Gabriel K. Griffin, Lucia Cabal-Hierro, Katsuhiro Togami, Leah J. Hogdal, Ilene Galinsky, Elizabeth A. Morgan, Jon C. Aster, Matthew S. Davids, Nicole R. LeBoeuf, Richard M. Stone, Marina Konopleva, Naveen Pemmaraju, Anthony Letai, Andrew A. Lane
Language: English
Open Access status: gold
OpenAlex ID: W4362538801
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