Supplementary Fig. S14 from Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors
Year: 2023
Type: supplementary-materials
Abstract: Depletion of adaptive immunity. Mice with 14 day tumors were injected intraperitoneal with depleting antibody (CD4, CD8, NK, IgG: 200 ug/mouse; Gr1: 60 ug/mouse) against indicated immune subsets 24hr prior to treatment with PEGPH20/shIDO-ST. Depletion antibodies were re-administered every 3 days. IVIS data are presented as (A) luminescent images, (B) quantitatively for each individual animal (n=6) and (C) collectively from multiple experiments. Groups were euthanized when {greater than or equal to}1 mouse reached endpoint (see Materials and Methods). Combined data only represents time points for groups where the total number of mice was still 6 (n=6). Statistical analyses were also performed for time points under these same criteria. **p{less than or equal to}0.01, Student's t test.
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362539734