Work

Supplementary Figures S1-S6 from Short-term PI3K Inhibition Prevents Breast Cancer in Preclinical Models

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure S1 show shows biochemical staining on MCF10A-PIK3CAH1047R mammary tumors. Supplementary Figure S2 shows expression of ERα in MCF10A-PIK3CAH1047R mammary tumors. Supplementary Figure S3 shows response of MCF10A-PIK3CAH1047R cells to fulvestrant in vitro and in vivo. Supplementary Figure S4 shows droplet digital PCR (ddPCR) analysis. Supplementary Figure S5 shows tolerance of alpelisib administration in mice. Supplementary Figure S6 shows short term alpelisib does not affect lung or bone metastasis from MCF10A-PIK3CAH1047R mammary tumors.

DOI: 10.1158/1940-6207.22535299.v1

Authors: Amy T. Ku, Adelaide I.J. Young, Ahmed Atef Ibrahim, Wen Bu, Weiyu Jiang, Meng Lin, Laterrica C. Williams, Bryant Lee McCue, George Miles, Chandandeep Nagi, Fariba Behbod, Yi Li

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362539905

Cites:

Cited by:

Related to: 10