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Supplementary Figure 2 from GM-CSF Mediates Mesenchymal–Epithelial Cross-talk in Pancreatic Cancer

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure 2. Pancreatic cancer associated MSCs promote tumor cell growth and invasion. A. GFP-labeled tumor cells were grown alone or co-cultured with CA-MSCs or CAFs. GFP-labeled tumor cells were grown in growth media, in combination with conditioned media (CM) from CA-MSCs and CM from CAFs. Increased tumor cell numbers when co-cultured with CA-MSC (A) or CA-MSC CM (A) demonstrate the ability of CA-MSCs to induce proliferation in the cancer cells. *p <0.05 vs growth medium for direct culture with CA-MSC and *p <0.0001 vs growth medium for culture with CA-MSC CM. B. Invasion assays demonstrating the impact of CA-MSCs (red) or CM from CA-MSCs on tumor cell (green) migration. Double headed arrows indicate extent of migration. *p <0.05 vs growth medium.

DOI: 10.1158/2159-8290.22531478

Authors: Meghna Waghray, Malica Yalamanchili, Michele Dziubinski, Mina Zeinali, Marguerite Erkkinen, Huibin Yang, Kara A. Schradle, Sumithra Urs, Marina Pasca Di Magliano, Theodore H. Welling, Phillip L. Palmbos, Ethan V. Abel, Vaibhav Sahai, Sunitha Nagrath, Lidong Wang, Diane M. Simeone

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362542497

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