Work

Supplementary Figure 5 - Low doses of Niraparib reduce the rate of DNA repair and sensitize cells to ionizing radiation from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Year: 2023

Type: supplementary-materials

Abstract: A, Several representative time points of SJG2 cells after immunofluorescent staining for γH2AX with DAPI as a counterstain after 1μM Niraparib, 2 Gy gamma radiation, or 2 Gy radiation pre-treated with 1μM Niraparib. Images were taken at indicated time points at 64X magnification.

DOI: 10.1158/1535-7163.22506091

Authors: Yevgen Chornenkyy, Sameer Agnihotri, Man Yu, Pawel Buczkowicz, Patricia Rakopoulos, Brian Golbourn, Livia Garzia, Robert Siddaway, Stephie Leung, James T. Rutka, Michael D. Taylor, Peter B. Dirks, Cynthia Hawkins

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362482215

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