Supplementary Table ST3 from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient
Year: 2023
Type: supplementary-materials
Abstract: All Exonic Variants which are present in ACRJ-PC28. SIFT, Polyphen2, LRT, MutationTaster, MutationAssessor, and CADD were used to predict variant effect. Pop_Freq_max is the maximum population frequency of the variant in 1000Genome Project (Aug 2015), Exome Sequence Project (ESP6500) and Genome Aggregation Database (gnomAD). Total_Damaging represents number of times the variant was predicted as damaging by the 5 methods used. There are 605 variants that are predicted as damaging for 5 methods (green) while 296 variants are predicted as damaging for 4 out of 5 methods (orange-brown), among them is the variant in ATM (rs147934285) (dk brown). 3). Additionally, 539 variants are predicted as damaging for 3 out of 5 methods (blue-purple). The data generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Authors: Henkel Valentine, William Aiken, Belinda Morrison, Ziran Zhao, Holly Fowle, Jason S. Wasserman, Elon Thompson, Warren Chin, Mark Young, Shannique Clarke, Denise Gibbs, Sharon Harrison, Wayne McLaughlin, Tim Kwok, Fang Jin, Kerry S. Campbell, Anelia Horvath, Rory Thompson, Norman H. Lee, Yan Zhou, Xavier Graña, Camille Ragin, Simone Badal
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362543048