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Supplementary Figure 1 from Preexisting MEK1 Exon 3 Mutations in V600E/KBRAF Melanomas Do Not Confer Resistance to BRAF Inhibitors

Year: 2023
Type: supplementary-materials
Abstract: PDF file - 181K, Patient tissues harboring concurrent and somatic B-RAF and MEK1 mutations. Chromatograms showing B-RAF exon 15 at V600 codon and MEK1 exon 3 at I111 or P124 codons in patient-matched normal tissue, baseline melanomas (prior to B-RAFi therapy), and melanomas on disease progression (i.e. at acquisition of B-RAFi resistance). Specific codons in red; N/A, not available.
DOI: 10.1158/2159-8290.22528619.v1
Authors: Hubing Shi, Gatien Moriceau, Xiangju Kong, Richard C. Koya, Ramin Nazarian, Gulietta M. Pupo, Antonella Bacchiocchi, Kimberly B. Dahlman, Bartosz Chmielowski, Jeffrey A. Sosman, Ruth Halaban, Richard F. Kefford, Georgina V. Long, Antoni Ribas, Roger S. Lo
Language: English
Open Access status: gold
OpenAlex ID: W4362543261
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