Supplementary Data from IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype
Year: 2023
Type: supplementary-materials
Abstract: Supp Fig 1 Compares IL2 alone to manufacturing platform. Supp Fig 2 Product post-enrichment. Supp Fig 3 Additional characterization of IL2 and IL15 cultured CAR-T cells. Supp Fig 4 Heat map comparing CD4 gene expression differences in IL2 and IL15 cultured CAR-T cells. Supp Fig 5 Additional phenotypic and functional characterizations Supp Fig 6 Comparison of PBMC-derived to CD62L-derived CAR-T cells in IL2 and IL15 culture condition. Supp Fig 7 Phenotypic and functional assessment of 4-1BB-CAR-T cultured in IL15 and IL2. Supp Fig 8 Comparison of expansion, �R+ and CD4/CD8 populations in CAR-T cells cultured in difference cytokine conditions. Supp Fig 9 Comparison of low-dose IL2 with IL15 alone and standard manufacturing platform IL2. Supp Table 1 Primer list
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362551613