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Supplementary Fig. S4 from Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors

Year: 2023

Type: supplementary-materials

Abstract: Pathology of peripheral organs in treated mice. Selected organs from mice given indicated treatments were reviewed histopathologically by hematoxylin/eosin stain. The liver shows portal and parenchymal inflammation with occasional foci of coagulative necrosis (N) in mice treated with PEGPH20/shIDO-ST or PEGPH20/shScr-ST, which also show minimal inflammatory changes within kidney (not shown) and pancreas. These findings can be ascribed to the use of Salmonella as a vector, since they are not seen in the PEGPH20 control mice. These findings have been documented previously using VNP20009 (13). Mild splenic hyperplasia is seen in all treated animals. Images shown are representative of multiple experiments.

DOI: 10.1158/2326-6066.22537496

Authors: Edwin R. Manuel, Jeremy Chen, Massimo D'Apuzzo, Melanie G. Lampa, Teodora I. Kaltcheva, Curtis B. Thompson, Thomas Ludwig, Vincent Chung, Don J. Diamond

Language: English

Topic: Cancer Research and Treatments

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362551963

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