Work

Supplemental Figure Legends 1-5 from TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors

Year: 2023

Type: supplementary-materials

Abstract: S1: Timeline of necrosis after CDN injection. S2: CDN injection causes a distinct cytokine and cellular profile in the tumor draining lymph nodes. S3: B16F10 is not directly killed by CDN exposure and behaves similarly to other mouse and human cell lines. S4: TNFα blockade reduces necrosis after IT CDN. S5: Outgrowth and CDN treatment of B16F10 is effected in selected knockout animals.

DOI: 10.1158/2326-6066.22540019

Authors: Brian J. Francica, Ali Ghasemzadeh, Anthony L. Desbien, Debebe Theodros, Kelsey E. Sivick, Gabrielle L. Reiner, Laura Hix Glickman, Ariel E. Marciscano, Andrew B. Sharabi, Meredith L. Leong, Sarah M. McWhirter, Thomas W. Dubensky, Drew M. Pardoll, Charles G. Drake

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362561037

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