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Supplementary methods, Supplementary tables 1 through 4, and Supplementary figure 1 from Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models

Year: 2023

Type: supplementary-materials

Abstract: Supplementary methods. Supplementary Table S1. Antibodies used in immune cell characterization by flow cytometry. Supplementary Table S2. PK parameters of ALT-803 administered to cynomolgus monkeys. Supplementary Table S3. Representative clinical characteristics of cynomolgus monkeys following 4 weekly doses of ALT-803 administration (study day 26). Supplementary Table S4. Incidence of major histopathologic findings in cynomolgus monkeys following 4 weekly doses of ALT-803 administration (study day 26). Supplementary Figure 1. Comparative binding of ALT-803 to IL-15 receptors on mouse, cynomolgus monkey, and human immune cells.

DOI: 10.1158/2326-6066.22538665.v1

Authors: Peter R. Rhode, Jack O. Egan, Wenxin Xu, Hao Hong, Gabriela M. Webb, Xiaoyue Chen, Bai Liu, Xiaoyun Zhu, Jinghai Wen, Lijing You, Lin Kong, Ana C. Edwards, Kaiping Han, Sixiang Shi, Sarah Alter, Jonah B. Sacha, Emily K. Jeng, Weibo Cai, Hing C. Wong

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362567224

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