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News beyond our pages

Year: 2023

Type: article

Abstract: Despite its universality, the molecular mechanisms underlying the aging process remain poorly understood. Liu et al (Cell 2023;186:287-304.e26; https://doi.org/10.1016/j.cell.2022.12.017) uncovered a positive feedback loop between the activation of dormant endogenous retroviruses and aging. More specifically, cellular senescence induced the reactivation and accumulation of the endogenous retrovirus HERVK. This in turn led to the production and extracellular release of retrovirus-like particles (RVLPs) that induced cellular senescence in neighboring young cells in a paracrine fashion.

Source: Journal of Allergy and Clinical Immunology

DOI: 10.1016/j.jaci.2023.02.006

Authors: Marc E. Rothenberg, Jean Bousquet

Institutions: Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Membrane Biology

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,000