Supplementary Figures 1 - 4 from ERK Phosphorylation Is Predictive of Resistance to IGF-1R Inhibition in Small Cell Lung Cancer
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 927K, Supplemental Figure 1 (associated with Figure 2). Expression of IGF-1R, IR, ERK, and AKT does not correlate with sensitivity to OSI-906 in SCLC cell lines. Supplemental Figure 2 (associated with Figure 4). Treatment with OSI-906 results in inhibition of phosphorylated IGF-1R and Akt, but not phosphorylated ERK, in both sensitive and resistant cell lines. Supplemental Figure 3. Inhibition of MEK or overexpression of an active MEK mutant does not alter SCLC sensitivity to OSI-906. Supplemental Figure 4. OSI-906 treatment induces cell cycle arrest in sensitive cell lines.
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362608970