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Supplementary Table 1 and Supplementary Figures 1 to 3 from Bisphosphonamidate Clodronate Prodrug Exhibits Selective Cytotoxic Activity against Melanoma Cell Lines

Year: 2023

Type: supplementary-materials

Abstract: PDF - 295K, Table S1. In vitro effects of CLO prodrug in NCI-60 cell screen. Table S2. In vitro effects of the CLO prodrug on SK-Mel-5 and UACC-62 melanoma cells. Figure S1. Bisphosphonamidate prodrugs are cell permeable and undergo intracellular activation in UACC-62 cells. Figure S2. CLO prodrug does not affect the viability of human keratinocytes and peripheral blood mononuclear cells. Figure S3. Intratumoral delivery of clodronate has no antitumor activity.

DOI: 10.1158/1535-7163.22499718

Authors: Marie R. Webster, Chandrashekhar Kamat, Nick Connis, Ming Zhao, Ashani T. Weeraratna, Michelle A. Rudek, Christine L. Hann, Caren L. Freel Meyers

Institutions: Johns Hopkins University, Johns Hopkins Medicine, The Wistar Institute, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362608991

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