Supplemental Figure 4 from Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure 4: Model of differential actions of MnTnBuOE-2-PyP5+ in causing the apoptosis of tumor during radiotherapy, while suppressing radation injury to surrounding normal tissue. Such effects are due to the differential redox environment of tumor vs normal cell, in particular much lower ability of cancer cell to remove cytotoxic hydrogen peroxide. Consequently, much higher levels of hydrogen peroxide already exist in tumor cell, and are greatly enhanced upon radiation. In normal cells and tissues, porphyrins suppress cycling inflammatory responses that may result from radiation also.
Authors: Douglas H. Weitzel, Artak Tovmasyan, Kathleen A. Ashcraft, Zrinka Rajic, Tin Weitner, Chunlei Liu, Wei Li, Anne F. Buckley, Mark R. Prasad, Kenneth H. Young, Ramona M. Rodriguiz, William C. Wetsel, Katherine B. Peters, Ivan Spasojevic, James E. Herndon, Ines Batinic-Haberle, Mark W. Dewhirst
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362609475