Supplementary Figures S1-S8 and Legends from HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Fig. S1. Identification of pitavastatin in IRIF persistence screen of NIH Clinical Collection in MCF7GFP-IBD and PANC02GFP-IBD cell lines; Supplementary Fig. S2. Mevalonic acid abrogates radiosensitization effects of pitavastatin in irradiated MCF7 GFP-IBD cells. Supplementary Fig. S3. Reduction in targeted protein expression by shRNA; Supplementary Fig. S4. Targeting mevalonate pathway affects protein prenylation; Supplementary Fig. S5. Farnesyl pyrophosphate abrogates radiosensitization effects of statins in irradiated MCF7 GFP-IBD cells; Supplementary Fig. S6. Silencing GGPS impacts DNA damage response; Supplementary Fig. S7. Clonogenic survival of B16.SIY cells treated with 5 μmol/L or 10 μmol/L veliparib 1 hour prior to the indicated irradiation dose; Supplementary Fig. S8. Flow cytometry co-staining assay for apoptosis and necrosis in tumor cells treated with pitavastatin and/or radiation.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362609741