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Supplementary Figure 2 from Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition

Year: 2023

Type: supplementary-materials

Abstract: Figure S2: Co-targeting S1P1 and VEGFR2 pathways induced reduction in permeability of retinal vessels. Ter 119 staining (panels A) visualize red blood cells and show that the combination of DC101 and the S1P1 antagonist in the retina led to reduction of the areas of hemorrhage within the vascular plexus and restricted only to the angiogenic front indicating that the remaining vessels in the remodeled area are less permeable.

DOI: 10.1158/1535-7163.22504639

Authors: Anthony S. Fischl, Xiaoen Wang, Beverly L. Falcon, Rowena Almonte-Baldonado, Diane Bodenmiller, Glenn Evans, Julie Stewart, Takako Wilson, Philip Hipskind, Jason Manro, Mark T. Uhlik, Sudhakar Chintharlapalli, Damien Gerald, David C. Alsop, Laura E. Benjamin, Rupal S. Bhatt

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362609772

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