Figure S1 from A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia
Year: 2023
Type: other
Abstract: Single agent treatment with olaparib or AZD1775 reduces cell viability and enhances apoptosis in AML and ALL cell lines. A. MV4;11, Molm13, Jurkat, and REH cells were treated with 0.25 uM- 20 uM olaparib for 72 hr. Percent of viable cells relative to cells receiving no treatment (NT) are shown. The IC50 value of each cell line is displayed. B. MV4;11, Molm13, Jurkat, and REH cells were treated with 0.25 uM- 20 uM olaparib for 72 hr and stained with Annexin V-PE. The EC50 value of each cell line is displayed. C. MV4;11, Molm13, Jurkat, and REH cells were treated with 25 nM - 2000 nM AZD1775 for 72 hr. Percent of viable cells relative to cells receiving no treatment (NT) are shown. The IC50 value of each cell line is displayed. D. MV4;11, Molm13, Jurkat, and REH cells were treated with 25 nM - 2000 nM AZD1775 for 72 hr and stained with Annexin V-PE. The EC50 value of each cell line is displayed.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362610135