Supplementary Materials and Methods; Supplementary Tables S1-S3; and Supplementary Figures S1-S3 from Repositioning Dopamine D2 Receptor Agonist Bromocriptine to Enhance Docetaxel Chemotherapy and Treat Bone Metastatic Prostate Cancer
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Materials and Methods; Supplementary Tables (Table S1. Antibodies used in Western blotting, immunoprecipitation and IHC studies. Table S2. Sequences of primers used for real-time PCR analysis. Table S3. Combination index (CI) of bromocriptine and docetaxel treatment in C4-2 cells); Supplementary Figures ( Figure S1. Quantitative PCR analysis of mRNA expression of AR and survivin in C4-2 cells treated with varying concentrations of bromocriptine (24 h). Figure S2. Body weights of athymic nude mice bearing C4-2-Luc tumors and treated with the vehicle control, docetaxel, bromocriptine and the combination. *: p < 0.05. Figure S3. Western blot analysis of p-AR (Ser650) expression in C4-2 cells treated with bromocriptine for varying times)
Authors: Yang Yang, Kenza Mamouni, Xin Li, Yanhua Chen, Sravan Kavuri, Yuhong Du, Haian Fu, Omer Kucuk, Daqing Wu
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362610467