Supplementary Figure S1 from Small Molecule–Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1
Year: 2023
Type: supplementary-materials
Abstract: Treatment with 1 does not cause total protein levels of SPRY2, SPRY4, DUSP4 and DUSP16 to increase. HeLa cells were treated with 50 μM 1 over a time course of up to 180 minutes. EGF (50 ng/mL for 5 minutes) was used as a positive control. HCT 116 lysate was included as a positive control for DUSP4 protein levels. Two biological repeats of this experiment were independently conducted.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362611819