Supp. Figure 1 from Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate
Year: 2023
Type: other
Abstract: Proton NMR spectra of LnCAP cell extracts treated either with DMSO or 1uM MK2206 for 24 hr. Co-factor concentrations were quantified as a ratio between the resonance for the lone hydrogen atom on the five membered ring of the adenine moiety in NAD+ that resonates at 8.435 ppm and NADH at 8.486 ppm. Extractions of cells were performed as described in the materials section.
Authors: Sui Seng Tee, Izabela Suster, Steven Truong, Sangmoo Jeong, Roozbeh Eskandari, Valentina DiGialleonardo, Julio A. Alvarez, Hannah N. Aldeborgh, Kayvan R. Keshari
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362612895