Supplementary Figure 2 from A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure 2 PDF file - 45K, Resistance to the MEK inhibitor AZD6244 induced by loss of NF1 is reversed by combined suppression of C-RAF by RNA interference. A375 cells were infected with the indicated shRNAs and then exposed to a 10-point titration of the MEK inhibitor AZD6244 for 4 d. Cell proliferation was assessed using cell-titer glo
Language: English
Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362615952