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Supplementary Figure 5 from Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 71K, Standard Curve for the quantitation of NVP-BKM120 in tumor cell lysates. Counts were measured from the peaks of the total ion current for NVP-BKM-120, integrated using MultiQuant v2.0 software (AB/SCIEX). For the concentration curve data, BKM-120 was prepared at concentrations of 1 nM, 10 nM, 100 nM, 500 nM, 1 muM and 10 muM in 40% methanol

DOI: 10.1158/2159-8290.22529214

Authors: Ashish Juvekar, Laura N. Burga, Hai Hu, Elaine P. Lunsford, Yasir H. Ibrahim, Judith Balmañà, Anbazhagan Rajendran, Antonella Papa, Katherine Spencer, Costas A. Lyssiotis, Caterina Nardella, Pier Paolo Pandolfi, José Baselga, Ralph Scully, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362616365

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