Work

Supplementary Figures S1 - S4 from PI3′-Kinase Inhibition Forestalls the Onset of MEK1/2 Inhibitor Resistance in BRAF-Mutated Melanoma

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Figure S1. BP2C mouse melanoma-derived cells are sensitive to PI3Kalpha-selective inhibition. Supplementary Figure S2. BRAFV600E/PTENNull melanoma-derived cells are sensitive to PI3Kalpha-sparing PI3'-kinase. Supplementary Figure S3. PI3Kalpha-sparing PI3K inhibition enhances the effects of MEK inhibition on BRAFV600E/PTENNull melanoma-derived cells inhibition. Supplementary Figure S4. BRAFV600E/PTENWT melanoma cells are sensitive to PI3Kalpha-sparing PI3'-kinase inhibition, and PI3Kalpha-sparing PI3K inhibition enhances the effects of MEK inhibition on BRAFV600E/ PTENWT melanoma cells.

DOI: 10.1158/2159-8290.22530425

Authors: Marian M. Deuker, Victoria Marsh Durban, Wayne A. Phillips, Martin McMahon

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362538392

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