Supplementary Information Figures 1-10, Videos 1-8 from Autocrine Fibronectin Inhibits Breast Cancer Metastasis
Year: 2023
Type: supplementary-materials
Abstract: S1. Differential fluorescent labeling of epithelial and mesenchymal cells. S2. Ca1h cells are not metastatic. S3. Fibronectin coated polystyrene induces a partial epithelialmesenchymal transition. S4. Fibronectin is in a fibular form in patient tumors. S5. Fibrillar fibronectin induction of EMT is dependent on the expression of b1 integrin. S6. Fibrillar fibronectin induces a mesenchymal phenotype. S7. Depletion of b1 increases intracellular FN. S8. Intracellular FN colocalizes with the actin cytoskeleton. S9. Systemically dormant cells express intracellular FN. S10.Depletion of FN increases pulmonary tumor proliferation.
Institution: Purdue University West Lafayette
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362616939