Supplementary figures from Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S1: RNA-seq analysis of human A375 melanoma cells in co-culture with adipocytes compared to monoculture controls Supplementary Figure S2: Lipid transfer and melanoma cell uptake of long chain fatty acids Supplementary Figure S3: Adipocytes do not increase glycolysis in melanoma cells Supplementary Figure S4: Endogenous FATP expression in control tissues and patient-derived xenografts Supplementary Figure S5: Absence of lipid-laden tumor cells in in vivo setting devoid of adipocytes Supplementary Figure S6: Lipidomics reveals specific lipid species transferred from adipocytes to melanoma cells Supplementary Figure S7: FATP1 expression and survival Supplementary Figure S8: Validation of FATP1 knockdown Supplementary Figure S9: Lipofermata targets FATP1 Supplementary Figure S10: Compounds that are structurally similar to Lipofermata do not cause decreases in lipid uptake or increased cell death Supplementary Figure S11: Measurement of apoptosis in Lipofermata-treated cells
Authors: Maomao Zhang, Julie S. Di Martino, Robert L. Bowman, Nathaniel R. Campbell, Sanjeethan C. Baksh, Theresa Simon-Vermot, Isabella S. Kim, Pearce Haldeman, Chandrani Mondal, Vladimir Yong-Gonzales, Mohsen Abu-Akeel, Taha Merghoub, Drew R. Jones, Xiphias Ge Zhu, Arshi Arora, Charlotte E. Ariyan, Kivanç Birsoy, Jedd D. Wolchok, Katherine S. Panageas, Travis Hollmann, Jose Javier Bravo-Cordero, Richard M. White
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362617040