Work

Movie 1 from Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery

Year: 2023

Type: other

Abstract: OT-I CTL engagement with H2B-GFP-labeled MEC1/OVA cells followed by target cell death. The migration tracks and position of individual CTLs (numbers) are highlighted. Arrowheads highlight different phases of target cell death, including membrane blebbing, chromatin condensation, nuclear fragmentation and fading of GFP fluorescence (green color). Time stamp, h:min. Scale bar, 20 µm.

DOI: 10.1158/2326-6066.22544304

Authors: Jeroen Slaats, Cindy E. Dieteren, Esther Wagena, Louis Wolf, Tonke K. Raaijmakers, Jeroen A. van der Laak, Carl G. Figdor, Bettina Weigelin, Peter Friedl

Institutions: Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, University of Tübingen, The University of Texas MD Anderson Cancer Center, Cancer Genomics Centre

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362620467

Cites: 38

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Related to: 10