Work

Supplemental Figure 1-3 from Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors

Year: 2023

Type: supplementary-materials

Abstract: Supplemental information contains three figures. Figure s1 displays plots of in vitro inhibition plotted versus IC50 values for inhibitors as measured for three individual cell lines. Figure S2 displays the low rate probability and religation inhibition measures of inhibition plotted versus the average normalized IC50 values for each of the four inhibitors. Figure S3 displays the fraction of relaxed DNA measured in the ensembled supercoil relaxation assay as a function of the inhibitor concentration for the four inhibitors.

DOI: 10.1158/1535-7163.22507114.v1

Authors: Yeonee Seol, Hongliang Zhang, Keli Agama, Nicholas Lorence, Yves Pommier, Keir C. Neuman

Language: English

Topic: Cancer therapeutics and mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362623552

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