Supplementary Figures 1-8 from An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure 1: Whole transcriptome analysis of U251 cells dosed with DFO and compounds 1 and 3; Supplementary Figure 2: Preliminary in vivo experiments - quantification of an uptake within of a radiolabeled Py-Im polyamide within tissues and subcellular localization of a fluorescently labeled compound; Supplementary Figure 3: Single-injection toxicity of a Py-Im polyamide 1; Supplementary Figure 4: Py-Im polyamide 1 attenuates tumor growth in GBM39 xenograftsu and explanation of dosing schedules and tumor growth curves for GBM39 tumors; Supplementary Figure 5: Mouse weight curves during treatment with Py-Im polyamide 1; Supplementary Figure 6: Measurements of vascular density for GBM39 tumors for two different dosing schedules; Supplementary Figure 7: In vivo Effects of treatment with 1 for GBM39 and U251 xenografts. Effects of treatment with 1 are consistent between GBM39 and U251 xenografts, and apoptosis results are consistent between TUNEL and CC3 staining. Supplementary Figure 8. Relation between HIF-1a accumulation and necrosis.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4362623626