Work

Supplementary Figures 1-6 from CDK4/6 Inhibitors Sensitize Rb-positive Sarcoma Cells to Wee1 Kinase Inhibition through Reversible Cell-Cycle Arrest

Year: 2023

Type: supplementary-materials

Abstract: Supplemental Figure 1: Schematic of HTSA and dose response curves of doxorubicin and AZD-1775 in different cell lines. Supplemental Figure 2: Cell cycle analysis following palbociclib treatment. Supplemental Figure 3: Schematic of combination index determination and combination index values of different drug combinations. Supplemental Figure 4: Combination treatment efficacy in SK-LMS1 Rb knockdown cells. Supplemental Figure 5: Western blot for apoptosis markers for SK-LMS1 cells treated with palbociclib. Supplemental Figure 6: Mouse weights over course of vehicle, single drugs and combination treatments.

DOI: 10.1158/1535-7163.22508457.v1

Authors: Ashleigh M. Francis, Angela Alexander, Yanna Liu, Smruthi Vijayaraghavan, Kwang Hui Low, Dong Yang, Tuyen Bui, Neeta Somaiah, Vinod Ravi, Khandan Keyomarsi, Kelly K. Hunt

Language: English

Topic: Advanced Breast Cancer Therapies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362623664

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