Supplementary Figures 1-6 from Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells
Year: 2023
Type: supplementary-materials
Abstract: Figure S1. LAPC-4 and CWR22RV1 are telomerase-positive ALT-negative cell lines. Figure S2. ATRXKOs were generated in LAPC-4 and CWR22Rv1 cells. Figure S3. Representative telomere restriction fragment (TRF) southern blots and signal intensity traces. Figure S4. TERT and TERC expression levels. Figure S5. CRISPR cas9 genome editing strategies targeting the TERC locus. Figure S6. RT-qPCR validation of genes differentially expressed in microarray.
Authors: Mindy K. Graham, Jiyoung Kim, Joseph Da, Jacqueline A. Brosnan-Cashman, Anthony Rizzo, Javier A. Baena Del Valle, Lionel Chia, Michael Rubenstein, Christine Davis, Qizhi Zheng, Leslie Cope, Michael Considine, Michael C. Haffner, Angelo M. De Marzo, Alan K. Meeker, Christopher M. Heaphy
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362623912