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Figure S4 from Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss–Driven Tumorigenesis

Year: 2023

Type: other

Abstract: Figure S4 related to Figure 4 shows that GDC-0980 reduces mTORC1 and PI3K signaling in Merlin-mutant Meso-33 cells and the MSK-LX19 PDX model, p27 levels are dramatically increased by combined MLN4914 and GDC-0980 therapy, and that the treatments in Figure 4 were well-tolerated.

DOI: 10.1158/1535-7163.22509961.v1

Authors: Jonathan Cooper, Qingwen Xu, Lu Zhou, Milica Pavlovic, Virginia Ojeda, Kamalika Moulick, Elisa de Stanchina, John T. Poirier, Marjorie Zauderer, Charles M. Rudin, Matthias A. Karajannis, C. Oliver Hanemann, Filippo G. Giancotti

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362623976

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