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Supplementary Material -Table Legends, Figures and Legends 1-3 from Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma

Year: 2023

Type: supplementary-materials

Abstract: S1. Doxycycline-inducible shRNA knockdown of BAP1 results in robust decrease of GLO1 expression in uveal melanoma cell lines. S2. Phenotypic rescue and toxicity analysis of three HDAC inhibitors in Xenopus embryos injected with control morpholino CtrlMO or bap1-targeting morpholino BAP1MO. S3. Quisinostat and trametinib combination exhibits mostly additive cytotoxic effect in uveal melanoma in vitro.

DOI: 10.1158/1541-7786.22525797.v1

Authors: Jeffim N. Kuznetsoff, Dawn A. Owens, Andy Lopez, Daniel A. Rodriguez, Nancy T. Chee, Stefan Kurtenbach, Daniel Bilbao, Evan R. Roberts, Claude-Henry Volmar, Claes Wahlestedt, Shaun P. Brothers, J. William Harbour

Institutions: Sylvester Comprehensive Cancer Center, University of Miami

Language: English

Topic: Ocular Oncology and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362625657

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