Supplementary Figures 1 - 10 from EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 2923KB, Supplementary Figure 1. Discordant pairs from whole-genome sequencing indicating the presence of multiple distinct EGFR rearrangements co-existing in individual TCGA samples. Supplementary Figure 2. Evaluation of the quality of whole-genome amplifications in SNS libraries. Supplementary Figure 3. EGFR amplification and rearrangements in BT325 and BT340. Supplementary Figure 4. Clonality analysis of BT325. Supplementary Figure 5. Detection of loss-of-heterozygosity in single nuclei by haplotype clustering. Supplementary Figure 6. Constructing the clonal hierarchy of 48 single nuclei derived from BT340. Supplementary Figure 7. Clonal alterations in BT325. Supplementary Figure 8. Complex rearrangements in BT340. Supplementary Figure 9. Interrogation of clonal alterations in single nuclei derived from BT325. Supplementary Figure 10. EGFRvII deletion mutant expressing Ba/F3 cells are sensitive to EGFR inhibitors.
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362626766