Table S3 from Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
Year: 2023
Type: other
Abstract: Table S3: Pathway Analysis of Intracranial and Subcutaneous Melanoma Xenografts. Results of EGSEA analyses of ICr (n=3) vs. SQ (n=3) tumors of 4 melanoma cell lines implanted into CD-1 nude mice. RNA-seq data were processed via Xenome to filter out contaminating mouse stromal signatures. "Gene Set" lists the database (MSigDB) and the specific collection of gene sets (Hallmark and c2: Curated) included in each analysis. Median rank was used to order the top 20 gene sets in each analysis. All gene sets listed have an adjusted p-value<0.001. Gene sets up-regulated in ICr tumors are shown in red. Gene sets down-regulated in ICr tumors are shown in blue. Of note, we identified no upregulation of nervous system gene sets in ICr xenografts and instead observed highly significant upregulation of numerous OXPHOS-related gene sets.
Authors: Grant M. Fischer, Ali Jalali, David A. Kircher, Won-Chul Lee, Jennifer L. McQuade, Lauren E. Haydu, Aron Y. Joon, Alexandre Reuben, Mariana P. de Macedo, Fernando C. L. Carapeto, Chendong Yang, Anuj Srivastava, Chandrashekar R. Ambati, Arun Sreekumar, Courtney W. Hudgens, Barbara Knighton, Wanleng Deng, Sherise D. Ferguson, Hussein A. Tawbi, Isabella C. Glitza, Jeffrey E. Gershenwald, Y. N. Vashisht Gopal, Patrick Hwu, Jason T. Huse, Jennifer A. Wargo, P. Andrew Futreal, Nagireddy Putluri, Alexander J. Lazar, Ralph J. DeBerardinis, Joseph R. Marszalek, Jianjun Zhang, Sheri L. Holmen, Michael T. Tetzlaff, Michael A. Davies
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362628148