Work

Supplementary Figures and Legends from Prostate Cancer Cells Express More Androgen Receptor (AR) Following Androgen Deprivation, Improving Recognition by AR-Specific T Cells

Year: 2023

Type: supplementary-materials

Abstract: S1. Phenotypic validation of HLA-A2-transfected 22Rv1/FCS and 22Rv1/CSS cells. S2. AR-specific T cells obtained following peptide-immunization have increased recognition and lysis of androgen-deprived prostate tumor cells. S3. Immunization with pTVG-AR delays tumor growth, in a CD8-dependent fashion, in the presence or absence of ADT. S4. Immunization with pTVG-AR delays tumor growth in the presence or absence of ADT, and results in increased tumor-infiltrating T cells.

DOI: 10.1158/2326-6066.22537862.v1

Authors: Brian M. Olson, Melissa Gamat, Joseph Seliski, Thomas Sawicki, Justin Jeffery, Leigh Ellis, Charles G. Drake, Jamey Weichert, Douglas G. McNeel

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362628679

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