Suppplementary Information from Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity
Year: 2023
Type: other
Abstract: Fig S1. Description of DNA constructs Fig S2. Distribution of intra-tumoral injected trypan blue Fig S3. Combination of intra-tumoral immunotoxins with anti-CTLA-4 is well tolerated by mice. Fig S4. Anti-tumor effect of anti-CTLA-4 and LMB-100 depends on CD8+ cells. Fig S5. High dose of SS1P is needed for induction of complete remission. Fig S6A & B. Anti-tumor effect of an immunotoxin targeting human CD22 & (B) Combination of SS1P with anti-CTLA-4 lead to tumor regressionof 66C14 tumors not expressing MSLN. Fig S7. Intra-tumors injection of paclitaxel does not improve the anti-tumor activity of anti-CTLA-4. Table S1. Combination of RIT and anti-CTLA-4 induces long-term anti-tumor immunity.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362618574