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Supplementary Figure S3. Gene expression in ADU-S100 treated tumors from neu/N mice. from A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice

Year: 2023

Type: supplementary-materials

Abstract: (A) 162 differentially expressed genes (Affymetrix Mouse Gene 2.0 ST array, 3 independent experiments, ANOVA p<0.05 and at least 2 fold change) induced by ADU-S100 IT injection on day 1 in tolerant neu/N mice. (B) The five most significant canonical pathways (Ingenuity Pathway Analysis) enriched 1 day after ADU-S100 IT injection in tolerant neu/N mice. P-values calculated using Fisher''s exact test. The orange points represent the ratio between the number of genes induced by IT ADU-S100 that belong to that specific pathway by the total number of genes annotated to that specific pathway. (C) Average mRNA values of C-C chemokines and CXC chemokines 1 and 7 days after IT ADU-S100 in tolerant neu/N mice. P-values calculated using ANOVA.

DOI: 10.1158/2326-6066.22539329.v1

Authors: Jeremy B. Foote, Marleen Kok, James M. Leatherman, Todd D. Armstrong, Bridget C. Marcinkowski, Laureen S. Ojalvo, David B. Kanne, Elizabeth M. Jaffee, Thomas W. Dubensky, Leisha A. Emens

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362629237

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