Work

Supplemental Figures and Tables from Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells

Year: 2023

Type: supplementary-materials

Abstract: Figure S1. Relative composition of TCRs in unsorted tumors within each treatment group. Figure S2. TCRβ CDR3 sequence distance among AH1-pentamer+/tetramer+CD8+ T cells. Table S1. Summary of TCR sequencing of whole 4T1 tumors. Table S2. Summary of TCR sequencing of AH1-pentamer+CD8+ T cells. Table S3. Abundance of AH1 clone signature (amino acid sequences) in CD4+ or CD8+ sorted T cells. Table S4. Three AH1 reactive T cell clones were shared between 4T1 tumors and AH1 peptide-vaccinated animals.

DOI: 10.1158/2326-6066.22539859.v1

Authors: Nils-Petter Rudqvist, Karsten A. Pilones, Claire Lhuillier, Erik Wennerberg, John-William Sidhom, Ryan O. Emerson, Harlan S. Robins, Jonathan Schneck, Silvia C. Formenti, Sandra Demaria

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362629239

Cites:

Cited by:

Related to: 10