Supplementary Figure S7. ADU-S100 sequenced with OX40 receptor ligation and PD-L1 blockade significantly delay tumor growth in distal un-injected tumors from neu/N mice. from A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice
Year: 2023
Type: supplementary-materials
Abstract: Neu/N mice were received 5 x 104 NT2.5 cells in the right cranial mammary fat pad (proximal injected) and left dorsal gluteal subcutaneous tissue (distal un-injected). When tumor sizes reached 62.5-mm3 (5 x 5 mm) neu/N mice were administered IT injections of ADU-S100 or HBSS with or without αOX40 receptor agonistic and αPD-L1 antagonistic antibodies as previously described in the material and methods section. Tumor growth in the injected NT2.5 tumor (proximal injected) and dorsal gluteal (distal un-injected) were evaluated over the course of 50 days. This data is cumulative of two independent experiments of 5 mice/group.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362629487