Supplementary Material, Supplementary Figures 1-6, Supplementary Tables 1 and 2 from Aberrant Induction of a Mesenchymal/Stem Cell Program Engages Senescence in Normal Mammary Epithelial Cells
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Information to: Aberrant induction of a mesenchymal/stem-cell program engages senescence in normal mammary epithelial cells S1. Cytokine-induced senescence induces EMT and SC-associated gene expression changes. S2. OSM-mediated Snail induction drives an aberrant EMT that induces senescence. S3. OSM-induced EMT requires STAT3- and TGF-β/SMAD3-mediated signaling. S4. Senescence-escape generates transformed CSC which are highly sensitive to palbociclib. S5. Proposed mechanisms of OSM induced senescence, EMT, and stemness in normal human epithelial cells versus transformed cells. S6. Uncropped images of all western blots presented in the current study (continued). Supplementary Table 1. List of primary antibodies used in this study Supplementary Table 2. qRT-PCR primer sequences (listed 5'-to-3') used in this study.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362635898