Supplementary File from Overlapping Functions of ABC Transporters in Topotecan Disposition as Determined in Gene Knockout Mouse Models
Year: 2023
Type: supplementary-materials
Abstract: Supplementary File - PDF file 584K, Supplementary Figure 1: Total topotecan pharmacokinetic variables in Abc transporters knock out mouse models at two i.v. dose levels. ; Supplementary Figure 2: Urinary and fecal excretions of total topotecan in Abc transporters knock out mouse models at two i.v. dose levels. ; Supplementary Figure 3: Biliary flow and excretion rate of total topotecan in Abc transporters knock out mouse models at two i.v. dose levels. ; Supplementary Figure 4: Concentration-time plots for topotecan lactone and total (lactone+carboxylate forms) forms in Abc transporters knock out mouse models at two i.v. dose levels. ; Supplementary Table 1. Topotecan resistance as determined in ABC transporter over-expressing cells through MTT assay. ; Supplementary Table 2. Selected total topotecan pharmacokinetic parameters in Abc transporter knock out strains at two i.v. dose levels. ; Supplementary Table 3. Clinical chemistry parameters in the Abc transporters knock out strains
Authors: Amit K. Tiwari, Rong Zhang, James M. Gallo
Institution: Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362609355