Diabetes Complications and Cognitive Function in Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: The SEARCH for Diabetes in Youth Study
Year: 2023
Type: article
Abstract: Aims/hypotheses: People with type 1 (T1D) or type 2 diabetes (T2D) who also have diabetes complications can have pronounced cognitive deficits. It remains unknown, however, whether and how multiple diabetes complications co-occur with cognitive dysfunction, particularly in youth-onset diabetes. Methods: Using data from the SEARCH for Diabetes in Youth study cohort, a prospective longitudinal cohort, we examined clustering of complications and their underlying clinical factors with performance on cognitive tests in young adults with youth-onset T1D or T2D. Cognition was assessed via the NIH Toolbox Cognition Battery. The main cognitive variables were age-corrected scores for composite fluid cognition and associated cognitive subdomains. Diabetes complications included retinopathy, microalbuminuria, and peripheral neuropathy (PN). Lipids, systolic blood pressure (SBP), hemoglobin A1c, and other clinical factors were included in the analyses. Clustering was applied separately to each group (T1D=646; T2D=165). A three-cluster(C) solution was identified for each diabetes type. Mean values and frequencies of all factors were compared between resulting clusters. Results: The average age-corrected score for composite fluid cognition differed significantly across clusters for each group (p<0.001). People with T1D and the lowest average fluid cognition scores had the highest frequency of self-reporting at least one episode of hypoglycemia in the year preceding cognitive testing and the highest prevalence of PN. Persons with T2D and the lowest average fluid cognition scores had the highest SBP, the highest central systolic and diastolic blood pressures, and highest prevalence of PN. Conclusions/interpretations: These findings highlight shared (PN) and unique factors (hypoglycemia in T1D; SBP in T2D) that could be targeted to potentially mitigate cognitive issues in young people with youth-onset diabetes.
Source: Pediatric Diabetes
DOI: 10.1155/2023/4860831
Authors: Allison L. B. Shapiro, Anna Bellatorre, Dana Dabelea, Jeanette M. Stafford, Ralph D’Agostino, Amy S. Shah, Elaine M. Urbina, Catherine E. Barrett, Catherine Pihoker, Santica Marcovina, Angela D. Liese, Amy K. Mottl, Elizabeth T. Jensen, Greta Wilkening
Institutions: University of Colorado Anschutz, Colorado School of Public Health, University of Colorado System, Wake Forest University, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Centers for Disease Control and Prevention, University of Washington, University of South Carolina, University of North Carolina at Chapel Hill, Wake Forest University Health Sciences
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,300
Awards: G1146718029, G1535104519, The neural underpinnings of disinhibited eating behavior in adolescents with and without obesity, SEARCH FOR DIABETES IN YOUTH REGISTRY STUDY, PHASE 4: CAROLINA CENTER (COMPONENT A), G2906879622, G3207814498, SEARCH FOR DIABETES IN YOUTH REGISTRY STUDY, PHASE 4: OHIO CENTER, G3837654701, G3869600316, SEARCH FOR DIABETES IN YOUTH REGISTRY STUDY, PHASE 4: WASHINGTON CENTER, THE SEARCH FOR DIABETES IN YOUTH REGISTRY STUDY, G4579419327, G4618533316, G4669381972, Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort Study, G486112768, G5212289133, G5304326513, G5724597403, G639100339, Limited Competition for the Closeout of the SEARCH for Diabetes in Youth Cohort Study, G7270065953, G7340126633, G7585356609, G7756189037, POPULATION-BASED DIABETES IN YOUTH REGISTRY. SEARCH FOR DIABETES IN YOUTH, PHASE 4, CALIFORNIA SITE, G7887311335, G7943243696, G8216919925, G8357409503, G8676770334, G8767603179
OpenAlex ID: W4362722487