Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis.
Year: 2023
Type: article
Abstract: -silenced cisplatin-exposed cells, indicating that cell cycle progression was inhibited. In conclusion, our results suggest that URI is involved in the cisplatin-induced DNA damage response via the ATM/CHK2 pathway, and silencing URI can increase cisplatin-induced DNA damage and enhance drug sensitivity in gastric cancer cells.
Source: PubMed Central
Authors: Huiqin Bian, Yu Gu, Chen Chen, Jinnan Chen, Fei Zhang, Zhonghai Xu, Qian Wang, Rui Mi, Xuan Wu, Yaojuan Lu, Qiping Zheng, Junxia Gu
Institutions: Jiangsu University, Affiliated Hospital of Jiangsu University
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Award: G3225605126
OpenAlex ID: W4363646963