Work

The ATPase activity of the phosphatidylethanolamine flippase TAT-5 inhibits extracellular vesicle budding from the plasma membrane

Year: 2023

Type: article

Abstract: mutant embryos and that phagocytosis was also disrupted. These data suggest that a low level of flippase activity can promote fertility, while a higher level of flippase activity is required to inhibit EV release, allow phagocytosis, and carry out embryonic development.

Source: PubMed Central

DOI: 10.17912/micropub.biology.000779

Authors: Lauren R Pitts, Julia Frondoni, Alexander T Nguyen, Ann M Wehman

Institution: University of Denver

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Deutsche Forschungsgemeinschaft, National Institutes of Health

Awards: G287150793, G8799960063, G9000028377, Caenorhabditis Genetics Center