Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells
Year: 2023
Type: article
Abstract: (Stem Cell Reports 10, 703–711; March 13, 2018) In the originally published version of the manuscript, Devon Bankler-Jukes, who assisted with mouse husbandry, feeding, and genotyping, as well as histological analysis, was inadvertently omitted from the author list. The corrected author list now appears with the manuscript online and the authors apologize for the oversight. Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem CellsYousefi et al.Stem Cell ReportsFebruary 22, 2018In BriefIn this study, Yousefi et al. identify reserve intestinal stem cell-autonomous suppression of mTORC1 activity in response to calorie restriction as the basis for enhanced regeneration of the intestinal epithelium after DNA-damaging injury. Conversely, the authors demonstrate that acute nutrient-based stimulation of mTORC1 prior to injury results in reserve stem cell apoptosis and intestinal regenerative failure. Full-Text PDF Open Access
Source: Stem Cell Reports
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,800
OpenAlex ID: W4364376668