Year: 2023
Type: article
Abstract: This short review summarizes our laboratory’s development of benzylboronic esters as nucleophiles. Activation of the benzylboronic ester is achieved by irreversible coordination of an alkyllithium Lewis base to form a nucleophilic benzylboronate. This boronate was found to react with aldehydes, imines, ketones, and alkyl bromides. A copper catalyst was employed in reactions of the boronate with epoxides and aziridines. 1 Introduction 2 1,2-Additions 3 Additions to sp3 Electrophiles 4 Conclusion and Outlook
Source: Synthesis
DOI: 10.1055/a-2072-2754
Authors: Timothy J. Barker, Andrew Bogatkevich, Dallas W. Crowder, Sophia G. Gierszal, Jacob C. Hayes, Michael R. Hollerbach, Richard W. Russell
Institution: College of Charleston
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G1403239016, South Carolina IDeA Network of Biomedical Research Excellence, G205870674, G2498696678, G529529811, G6251289876, G7109986697, South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE), MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer with a Multinuclear Probe and a Sample Changer, G9000222242, G9000304934, G9000355285
OpenAlex ID: W4365133669