Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice
Year: 2023
Type: article
Abstract: This study provides evidence that hypothalamic gliosis is a key early event through which androgen deficiency in combination with a Western-style diet might lead to cardiometabolic dysregulation in males. Furthermore, this work provides the first evidence in humans of a positive association between hypothalamic gliosis and LDL-cholesterol, advancing our knowledge of CNS influences on CVD risk progression.
Institution: University of Washington
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1228426491, APOC3 mediated dyslipidemia in diabetic kidney disease and atherosclerosis, Sex-specific microglial signaling in the pathogenesis of obesity and diabetes, Role of estrogens in hypothalamic inflammation and metabolic regulation., Central regulation of atherosclerosis by testosterone-deficiency, Nutrition Obesity Research Center, Diabetes Research Center, Identifying new strategies for prevention of cardiovascular complications of diabetes, Fostering patient-oriented research in cardiometabolic disease pathogenesis and prevention, Metabolic Regulation by Microglial Inflammatory Signaling, Diabetes, Obesity and Metabolism Training Program
OpenAlex ID: W4365442618